Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00079)
Xenobiotics Name
Vorinostat
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5311
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2], [3]
Arylsulfatase B (ARSB) DME Info Homo sapiens [3]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [4], [5]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [5]
DOPA decarboxylase (DDC) DME Info Homo sapiens [2], [6]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [3]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [3]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [3]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [2], [6]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [3]
Thymidylate synthase (TYMS) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info Homo sapiens [2], [6]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [2]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [7], [5]
Folylpolyglutamate synthase (FPGS) DME Info Homo sapiens [4]
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [5]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [3]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [7]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [8]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [7]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [2], [5]
Thiopurine methyltransferase (TPMT) DME Info Homo sapiens [1]
References
1 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
2 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
3 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
4 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
5 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
6 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
7 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
8 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.

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