Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00095)
Xenobiotics Name
Testosterone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
6013
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [2]
Hypoxanthine phosphoribosyltransferase (HPRT1) DME Info Homo sapiens [3]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [3]
Thymidylate synthase (TYMS) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [5]
DME(s) Induced by This Xenobiotics
Arylsulfatase A (ARSA) DME Info Homo sapiens [6], [3]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [7]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [7]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [5]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [8]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [3]
Glutathione reductase (GSR) DME Info Homo sapiens [9]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [3]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [3]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [10]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [10]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [10]
Methylenetetrahydrofolate reductase (MTHFR) DME Info Homo sapiens [1]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [11]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [12]
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [9]
Transglutaminase H (TGM2) DME Info Homo sapiens [3]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info Homo sapiens [12], [13]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [5]
References
1 The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9.
2 Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies. Chem Biol Interact. 2015 Mar 25;230:1-8.
3 The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food Chem Toxicol. 2019 Jan;123:481-491.
4 Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol. 2002 Jul 1;182(1):44-54.
5 Potential anticancer activity of tanshinone IIA against human breast cancer. Int J Cancer. 2005 Sep 20;116(5):799-807.
6 Combination effects of (tri)azole fungicides on hormone production and xenobiotic metabolism in a human placental cell line. Int J Environ Res Public Health. 2014 Sep 17;11(9):9660-79.
7 Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line. Toxicol Appl Pharmacol. 2011 Apr 1;252(1):18-27.
8 Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines. Arch Toxicol. 2019 May;93(5):1311-1322.
9 Green tea attenuates benzene-induced oxidative stress in pump workers. J Immunotoxicol. 2008 Jan;5(1):69-80.
10 Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
11 Taurocholate induces cyclooxygenase-2 expression via the sphingosine 1-phosphate receptor 2 in a human cholangiocarcinoma cell line. J Biol Chem. 2015 Dec 25;290(52):30988-1002.
12 Structure-dependent modulation of aryl hydrocarbon receptor-mediated activities by flavonoids. Toxicol Sci. 2018 Jul 1;164(1):205-217.
13 Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. Phytother Res. 2012 Nov;26(11):1746-52.

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