Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00096)
Xenobiotics Name
Ampicillin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
6249
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1], [2]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [2]
Asparagine synthetase (ASNS) DME Info Homo sapiens [2]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [2]
Glutamate decarboxylase (gadB) DME Info Listeria monocytogenes [3]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [4]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [4]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [5]
NADPH-dependent nitroreductase (nfrA1) DME Info Bacillus subtilis [6]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [4]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [7]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [2]
Glutamate racemase (MurI) DME Info Bacillus subtilis [6]
Glutamate racemase (MurI) DME Info Bacillus pumilus [6]
General stress protein 14 (ywrO) DME Info Bacillus subtilis [6]
DME(s) Induced by This Xenobiotics
Carboxylesterase 1 (CES1) DME Info Homo sapiens [8]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [8]
References
1 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
2 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
3 Role of PBPD1 in stimulation of Listeria monocytogenes biofilm formation by subminimal inhibitory beta-lactam concentrations. Antimicrob Agents Chemother. 2014 Nov;58(11):6508-17.
4 An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. Nat Prod Res. 2017 May;31(10):1177-1180.
5 Inhibitory effect of Duabanga grandiflora on MRSA biofilm formation via prevention of cell-surface attachment and PBP2a production. Molecules. 2015 Mar 10;20(3):4473-82.
6 Examine the characterization of biofilm formation and inhibition by targeting SrtA mechanism in Bacillus subtilis: a combined experimental and theoretical study. J Mol Model. 2014 Aug;20(8):2364.
7 Effects of some antibiotics on paraoxonase from human serum in vitro and from mouse serum and liver in vivo. Biol Pharm Bull. 2006 Aug;29(8):1559-63.
8 Evaluation of the sensitizing potential of antibiotics in vitro using the human cell lines THP-1 and MUTZ-LC and primary monocyte-derived dendritic cells. Toxicol Appl Pharmacol. 2012 Aug 1;262(3):283-92.

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