Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00121)
Xenobiotics Name
Etoposide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
36462
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [3]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [4]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [5]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [4]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
References
1 Effect of functionalized and non-functionalized nanodiamond on the morphology and activities of antioxidant enzymes of lung epithelial cells (A549). Chem Biol Interact. 2014 Oct 5;222:135-47.
2 The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. Toxicology. 2018 Apr 1;398-399:1-12.
3 Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J Biol Chem. 2007 Oct 12;282(41):29847-54.
4 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
5 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.

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