Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00125)
Xenobiotics Name
Simvastatin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
54454
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [2]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [3]
Myeloperoxidase (MPO) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1]
Thymidylate synthase (TYMS) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [5]
Indoleamine 2,3-dioxygenase 1 (IDO1) DME Info Homo sapiens [6]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [1], [4]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [7]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2C8 (CYP2C8) DME Info IC50 = 3.7 microM [2]
HMG-CoA reductase (HMGCR) DME Info IC50 = 0.0009 microM [3]
References
1 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015 Apr 18;16:315.
2 Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug Metab Dispos. 2012 May;40(5):943-51.
3 Natural-products-inspired use of the gem-dimethyl group in medicinal chemistry. J Med Chem. 2018 Mar 22;61(6):2166-2210.
4 Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet. 2015 Mar 1;24(5):1374-89.
5 Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. Mol Pharm. 2013 Aug 5;10(8):3242-52.
6 Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines. Chem Biol Interact. 2013 Jun 25;204(1):28-38.
7 Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells. Toxicology. 2012 Sep 28;299(2-3):112-24.

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