Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00127)
Xenobiotics Name
Mifepristone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
55245
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [1]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info Ki = 4.7 microM [2]
References
1 Evaluation of an in vitro model of androgen ablation and identification of the androgen responsive proteome in LNCaP cells. Proteomics. 2007 Jan;7(1):47-63.
2 Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54.
3 Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells. Oncogene. 2006 Nov 23;25(55):7311-23.

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