Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00129)
Xenobiotics Name
Finasteride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
57363
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [1]
Steroid 5-alpha-reductase 2 (SRD5A2) DME Info Homo sapiens [2], [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Steroid 5-alpha-reductase 1 (SRD5A1) DME Info IC50 = 0.0198 microM [1]
Steroid 5-alpha-reductase 2 (SRD5A2) DME Info IC50 < 0.0001 microM [2], [3]
References
1 A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2361-3.
2 4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductasesDramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency. J Med Chem. 1995 Aug 18;38(17):3189-92.
3 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J Med Chem. 1994 Nov 11;37(23):3871-4.

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