Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00147)
Xenobiotics Name
Fulvestrant
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
104741
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [2], [3]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [4]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5], [6]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [6]
Neprilysin (MME) DME Info Homo sapiens [7]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [8]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [9]
References
1 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
2 Modulation of aromatase expression in human breast tissue. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):35-40.
3 Selective oestrogen receptor modulators, aromatase inhibitors and the female breast. Curr Opin Obstet Gynecol. 2005 Aug;17(4):429-34.
4 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
5 Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
6 Red clover aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) agonists enhance genotoxic estrogen metabolism. Chem Res Toxicol. 2017 Nov 20;30(11):2084-2092.
7 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
8 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
9 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.

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