Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00156)
Xenobiotics Name
Naproxen
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
156391
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aldo-keto reductase 1C1 (AKR1C1) DME Info IC50 > 100 microM [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info IC50 = 31.3 microM [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info IC50 = 0.48 microM [2]
Prostaglandin G/H synthase 1 (COX-1) DME Info IC50 = 0.211 microM [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 1010 microM [4]
References
1 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3 J Med Chem. 2012 Sep 13;55(17):7746-58.
2 Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5170-5.
3 Pharmacodynamic of cyclooxygenase inhibitors in humans. Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):85-94.
4 Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod. 1998 Oct;61(10):1212-5.
5 Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chem Biol Interact. 2015 Jun 5;234:114-25.

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