Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00159)
Xenobiotics Name
Bortezomib
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
387447
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Succinate-semialdehyde dehydrogenase (ALDH5A1) DME Info Homo sapiens [1]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [1]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [2]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [2]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [2]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info Homo sapiens [1]
Glutathione reductase (GSR) DME Info Homo sapiens [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [1]
Phosphorylcholine transferase A (PCYT1A) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
References
1 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
2 Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. Chem Biol Interact. 2011 May 30;191(1-3):239-49.

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