Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00166)
Xenobiotics Name
Diethylstilbestrol
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
448537
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [2]
Aromatase (CYP19A1) DME Info Homo sapiens [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [2]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [2]
Proline dehydrogenase 1 (PRODH) DME Info Homo sapiens [4]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [4]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [5]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [6]
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [4]
Carbonic anhydrase II (CA2) DME Info Homo sapiens [4]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [7]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [8]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [4]
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [9]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [10], [11]
References
1 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
2 Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells. J Cell Biochem. 2003 Jul 1;89(4):755-70.
3 Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol Appl Pharmacol. 2007 Jul 15;222(2):129-40.
4 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
5 Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Anal Biochem. 2006 Oct 1;357(1):85-92.
6 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
7 Use of comprehensive screening methods to detect selective human CAR activators. Biochem Pharmacol. 2011 Dec 15;82(12):1994-2007.
8 Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: implications for toxicity testing paradigms. Reprod Toxicol. 2013 Jun;37:24-30.
9 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
10 Assaying estrogenicity by quantitating the expression levels of endogenous estrogen-regulated genes. Environ Health Perspect. 2000 May;108(5):403-12.
11 Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters. Hum Reprod. 2001 May;16(5):1037-45.

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