Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00168)
Xenobiotics Name
Decitabine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
451668
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [1]
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [3], [4]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [5]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [6], [7]
Folylpolyglutamate synthase (FPGS) DME Info Homo sapiens [8]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [9]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [10]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [11]
Metallothionein-2A (MT2A) DME Info Homo sapiens [12]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [1]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [6]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [13]
References
1 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
2 Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells. Toxicology. 2011 Jul 29;285(3):97-103.
3 Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers. Pharmacogenomics J. 2009 Jun;9(3):208-17.
4 In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation. Pharmacol Res Perspect. 2017 Mar 2;5(2):e00299.
5 Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. Biochem Cell Biol. 2007 Jun;85(3):337-46.
6 Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
7 Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chin Med J (Engl). 2007 Sep 20;120(18):1626-31.
8 Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells. J Biol Chem. 2001 Oct 26;276(43):39990-40000.
9 Downregulation of glutathione S-transferase M1 protein in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced mouse bladder carcinogenesis. Toxicol Appl Pharmacol. 2014 Sep 15;279(3):322-330.
10 GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: regulation by promoter methylation and extracellular regulated kinase signaling. Anticancer Drugs. 2009 Mar;20(3):208-14.
11 Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest. 2004 Oct;114(8):1146-57.
12 The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-186.
13 Epigenetic regulation is a crucial factor in the repression of UGT1A1 expression in the human kidney. Drug Metab Dispos. 2013 Oct;41(10):1738-43.

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