Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00189)
Xenobiotics Name
Topiramate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5284627"></iframe>
3D MOL 2D MOL
PubChem CID
5284627
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Carbonic anhydrase II (CA2) DME Info Homo sapiens [1]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Carbonic anhydrase II (CA2) DME Info IC50 = 0.005 microM [1]
References
1 Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride. Bioorg Med Chem Lett. 2004 Jan 19;14(2):337-41.
2 Systems toxicology assessment of the biological impact of a candidate modified risk tobacco product on human organotypic oral epithelial cultures. Chem Res Toxicol. 2016 Aug 15;29(8):1252-69.
3 Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures. Food Chem Toxicol. 2019 Mar;125:252-270.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.