Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00193)
Xenobiotics Name
Belinostat
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6918638"></iframe>
3D MOL 2D MOL
PubChem CID
6918638
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [1]
Adenosine aminohydrolase (ADA) DME Info Homo sapiens [2], [1]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
DOPA decarboxylase (DDC) DME Info Homo sapiens [1]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [1]
Thymidylate synthase (TYMS) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [2]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [2]
Phosphodiesterase 7B (PDE7B) DME Info Homo sapiens [1]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [2]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [2], [3]
References
1 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
2 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
3 Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. Anticancer Drugs. 2009 Sep;20(8):682-92.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.