Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00213)
Xenobiotics Name
Aspirin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2244
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Adenine phosphoribosyltransferase (APRT) DME Info Homo sapiens [2]
Bleomycin hydrolase (BLMH) DME Info Homo sapiens [3]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [3]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [4]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [6]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [7]
DME(s) Induced by This Xenobiotics
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [8]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [9]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [10]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [11]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [12]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Prostaglandin G/H synthase 1 (COX-1) DME Info IC50 = 100 microM [4]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 100 microM [5]
References
1 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
2 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
3 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
4 Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damagedesign and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24;51(8):2400-11.
5 Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Bioorg Med Chem. 2007 Sep 15;15(18):6109-18.
6 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
7 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
8 Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression. Atherosclerosis. 2005 Nov;183(1):49-55.
9 Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase. J Physiol Pharmacol. 2006 Nov;57 Suppl 5:125-36.
10 Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. Chem Res Toxicol. 2012 Dec 17;25(12):2725-36.
11 Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
12 Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.

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