Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00218)
Xenobiotics Name
Caffeine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2519
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2], [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [4]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [5]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [6]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [6]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [6]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [7]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 4B1 (CYP4B1) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [8]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [9]
References
1 Caffeine overcomes genistein-induced G2/M cell cycle arrest in breast cancer cells. Nutr Cancer. 2008;60(3):382-8.
2 Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. Xenobiotica. 2001 Mar;31(3):135-51.
3 An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine. Toxicol In Vitro. 2014 Mar;28(2):231-9.
4 Gene expression changes associated with cytotoxicity identified using cDNA arrays. Funct Integr Genomics. 2000 Sep;1(2):114-26.
5 Caffeine reduces 11beta-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor. PLoS One. 2012;7(6):e38082.
6 Trigonella foenum-graceum (Seed) extract interferes with quorum sensing regulated traits and biofilm formation in the strains of pseudomonas aeruginosa and aeromonas hydrophila. Evid Based Complement Alternat Med. 2015;2015:879540.
7 Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. J Biol Chem. 2011 Jul 1;286(26):22825-32.
8 Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats. Toxicology. 2019 Apr 15;418:11-21.
9 Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos. 2008 May;36(5):816-23.

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