Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00233)
Xenobiotics Name
Aminoglutethimide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2145
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [2]
Peroxisomal multifunctional enzyme 2 (HSD17B4) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Catechol O-methyltransferase (COMT) DME Info Homo sapiens [4]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Steroid 17-alpha-monooxygenase (CYP17A1) DME Info IC50 = 60 microM [1]
Aromatase (CYP19A1) DME Info IC50 = 0.0052 microM [2]
References
1 Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones. J Med Chem. 1991 Apr;34(4):1329-34.
2 Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64.
3 The H295R system for evaluation of endocrine-disrupting effects. Ecotoxicol Environ Saf. 2006 Nov;65(3):293-305.
4 Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.

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