Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00245)
Xenobiotics Name
Felodipine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
3333
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1], [2]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [3]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [3]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [3]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2C9 (CYP2C9) DME Info IC50 = 4.5795 microM [3]
References
1 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
2 In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of gama-hydroxybutyrate (GHB) binding. Toxicol In Vitro. 2017 Apr;40:196-202.
3 Optical isomers of dihydropyridine calcium channel blockers display enantiospecific effects on the expression and enzyme activities of human xenobiotics-metabolizing cytochromes P450. Toxicol Lett. 2016 Nov 16;262:173-186.
4 Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine. Chem Biol Interact. 2019 Jun 1;306:1-9.

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