Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00246)
Xenobiotics Name
Amoxicillin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
33613
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1]
Glutamate decarboxylase (gadB) DME Info Listeria monocytogenes [2]
NADPH-dependent nitroreductase (nfrA1) DME Info Bacillus subtilis [3]
Glutamate racemase (MurI) DME Info Bacillus subtilis [3]
Glutamate racemase (MurI) DME Info Bacillus pumilus [3]
General stress protein 14 (ywrO) DME Info Bacillus subtilis [3]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [4]
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [5]
Aromatase (CYP19A1) DME Info Homo sapiens [5]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [4]
References
1 Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. J Toxicol Sci. 2016 Feb;41(1):143-6.
2 Role of PBPD1 in stimulation of Listeria monocytogenes biofilm formation by subminimal inhibitory beta-lactam concentrations. Antimicrob Agents Chemother. 2014 Nov;58(11):6508-17.
3 Examine the characterization of biofilm formation and inhibition by targeting SrtA mechanism in Bacillus subtilis: a combined experimental and theoretical study. J Mol Model. 2014 Aug;20(8):2364.
4 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
5 Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicol Appl Pharmacol. 2007 Dec 1;225(2):142-53.

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