Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00256)
Xenobiotics Name
Paclitaxel
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
4666
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [2]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [3]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [4]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
Uridine 5'-monophosphate synthase (UMPS) DME Info Homo sapiens [5]
DME(s) Induced by This Xenobiotics
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [6]
Thymidylate synthase (TYMS) DME Info Homo sapiens [7]
References
1 AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor. Toxicol Sci. 2014 May;139(1):198-209.
2 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
3 Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases. Chem Biol Interact. 2008 Sep 25;175(1-3):305-8.
4 Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells. Toxicol Appl Pharmacol. 2007 Aug 15;223(1):28-38.
5 Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. Eur J Cancer. 2009 Nov;45(16):2882-92.
6 Neuroprotective effects of glyceryl nonivamide against microglia-like cells and 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y human dopaminergic neuroblastoma cells. J Pharmacol Exp Ther. 2007 Dec;323(3):877-87.
7 Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB. Toxicol Appl Pharmacol. 2015 Jul 15;286(2):92-101.

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