Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00267)
Xenobiotics Name
Ethinyl estradiol
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5991
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [3]
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME Info Homo sapiens [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [5]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [1]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [6]
DME(s) Induced by This Xenobiotics
Carbonic anhydrase II (CA2) DME Info Homo sapiens [1]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info Ki = 18 microM [5]
References
1 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
2 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
3 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
4 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
5 Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54.
6 Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Anal Biochem. 2006 Oct 1;357(1):85-92.

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