Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00277)
Xenobiotics Name
Amiodarone hydrochloride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
441325
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1], [2]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [3]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [5]
Asparagine synthetase (ASNS) DME Info Homo sapiens [6], [7]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [5]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [8]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [8]
Vitamin D 25-hydroxylase (CYP2R1) DME Info Homo sapiens [8]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [9]
Glutathione S-transferase omega-2 (GSTO2) DME Info Homo sapiens [8]
Phosphodiesterase 7B (PDE7B) DME Info Homo sapiens [8]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [8]
Sulfotransferase 1A3 (SULT1A3) DME Info Homo sapiens [8]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [8]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2C8 (CYP2C8) DME Info Ki = 1.5 microM [3]
References
1 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
2 QT interval prolongation and Torsades de Pointes in a patient receiving zolpidem and amiodarone. Cardiology. 2006;105(3):146-7.
3 Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54.
4 Assessment of drug-drug interactions caused by metabolism-dependent cytochrome P450 Inhibition. Chem Biol Interact. 2012 Jun 25;198(1-3):49-56.
5 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
6 In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
7 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
8 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
9 Phospholipidosis induced by PPARgama signaling in human bronchial epithelial (BEAS-2B) cells exposed to amiodarone. Toxicol Sci. 2011 Mar;120(1):98-108.

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