Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00278)
Xenobiotics Name
Beclomethasone dipropionate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
21700
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [1]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [2]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [3]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [5]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [6]
Gamma-glutamyltranspeptidase 5 (GGT5) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [8]
References
1 Bone metabolism in children with asthma treated with inhaled beclomethasone dipropionate. J Pediatr. 1993 Feb;122(2):219-26.
2 CYP2S1 is negatively regulated by corticosteroids in human cell lines. Toxicol Lett. 2012 Feb 25;209(1):30-4.
3 Correlation between change in pulmonary function and suppression of reactive nitrogen species production following steroid treatment in COPD. Thorax. 2003 Apr;58(4):299-305.
4 Comparison of in vitro-activity of commonly used topical glucocorticoids on cytokine- and phospholipase inhibition. Eur J Med Res. 2004 Aug 31;9(8):383-90.
5 Changes in levels of catalase and glutathione in erythrocytes of patients with stable asthma, treated with beclomethasone dipropionate. Eur Respir J. 1999 Jun;13(6):1260-6.
6 Regulation of CYP3A genes by glucocorticoids in human lung cells. F1000Res. 2013 Aug 13;2:173.
7 A novel pharmacologic action of glucocorticosteroids on leukotriene C4 catabolism. J Allergy Clin Immunol. 2001 Jul;108(1):122-4.
8 Induction of drug-metabolizing enzymes and transporters in human bronchial epithelial cells by beclomethasone dipropionate. IUBMB Life. 2004 Jun;56(6):355-9.

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