Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00296)
Xenobiotics Name
Flurbiprofen sodium
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=23684814"></iframe>
3D MOL 2D MOL
PubChem CID
23684814
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4], [3]
DME(s) Induced by This Xenobiotics
Quinone reductase 1 (NQO1) DME Info Homo sapiens [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aldo-keto reductase 1C1 (AKR1C1) DME Info IC50 > 100 microM [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info IC50 = 32.5 microM [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info IC50 = 1.56 microM [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info IC50 = 0.01 microM [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 0.01 microM [4], [3]
References
1 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3 J Med Chem. 2012 Sep 13;55(17):7746-58.
2 Flurbiprofen inhibits androgen productions in rat immature leydig cells. Chem Res Toxicol. 2019 Aug 19;32(8):1504-1514.
3 Structural and functional basis of cyclooxygenase inhibition. J Med Chem. 2007 Apr 5;50(7):1425-41.
4 Structure-based design of COX-2 selectivity into flurbiprofen. Bioorg Med Chem Lett. 1999 Feb 8;9(3):307-12.
5 Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity: evidence for a NAD(P)H:quinone reductase-dependent mechanism. Arch Toxicol. 1995;69(10):684-9.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.