Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00312)
Xenobiotics Name
Nicotine polacrilex
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
89594
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [1], [2]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [3]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [4]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [5]
Cytochrome P450 2A13 (CYP2A13) DME Info Homo sapiens [6]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [7]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [8]
DME(s) Induced by This Xenobiotics
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [9]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [10], [11]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [12]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [13]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [9]
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [5]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [5], [14]
Neprilysin (MME) DME Info Homo sapiens [9]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [7]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [14]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A2 (CYP1A2) DME Info IC50 = 4100 microM [4]
Cytochrome P450 2A13 (CYP2A13) DME Info Ki = 72 microM [6]
References
1 Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
2 Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
3 The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. J Immunol. 2007 Mar 1;178(5):3198-207.
4 Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
5 Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.
6 Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes. Drug Metab Dispos. 2012 Sep;40(9):1797-802.
7 Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):131-49.
8 Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway. Toxicol Sci. 2009 Jan;107(1):227-37.
9 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
10 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
11 MIP-1beta, a novel biomarker for in vitro sensitization test using human monocytic cell line. Toxicol In Vitro. 2006 Aug;20(5):736-42.
12 Cancer stem-like cells accumulated in nickel-induced malignant transformation. Toxicol Sci. 2016 Jun;151(2):376-87.
13 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
14 Transcriptional profiling defines the effects of nickel in human epidermal keratinocytes. J Cell Physiol. 2008 Dec;217(3):686-92.

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