Detail Information of Xenobiotics
| General Information of Xenobiotics (ID: XEO00317) | ||||||
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| Xenobiotics Name |
Pentamidine isethionate
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| Xenobiotics Type |
Pharmaceutical Agent(s)
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| Classification |
Approved/Marketed Drug
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| Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=8813"></iframe>
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| 3D MOL | 2D MOL | |||||
| PubChem CID | ||||||
| DME(s) Modulated by This Xenobiotics | ||||||
| DME(s) Inhibited by This Xenobiotics | ||||||
| Mephenytoin 4-hydroxylase (CYP2C19) | DME Info | Homo sapiens | [1] | |||
| Cytochrome P450 2C9 (CYP2C9) | DME Info | Homo sapiens | [1] | |||
| Cytochrome P450 2D6 (CYP2D6) | DME Info | Homo sapiens | [1] | |||
| Cytochrome P450 3A4 (CYP3A4) | DME Info | Homo sapiens | [1] | |||
| Xenobiotics-DME Activity Data | ||||||
| Xenobiotics-DME Activity Data | Mephenytoin 4-hydroxylase (CYP2C19) | DME Info | IC50 > 100 microM | [1] | ||
| Cytochrome P450 2C9 (CYP2C9) | DME Info | IC50 > 100 microM | [1] | |||
| Cytochrome P450 2D6 (CYP2D6) | DME Info | IC50 = 24.8 microM | [1] | |||
| Cytochrome P450 3A4 (CYP3A4) | DME Info | IC50 > 100 microM | [1] | |||
| References | ||||||
| 1 | Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds. Eur J Med Chem. 2017 Jan 27;126:1129-1135. | |||||
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