Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00328)
Xenobiotics Name
Tacrine hydrochloride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2723754"></iframe>
3D MOL 2D MOL
PubChem CID
2723754
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [1]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Acetylcholinesterase (ACHE) DME Info IC50 = 0.00316 microM [1]
Butyrylcholine esterase (BCHE) DME Info IC50 = 0.0000267 microM [1]
Carboxylesterase 1 (CES1) DME Info IC50 > 100 microM [2]
References
1 Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors. Eur J Med Chem. 2011 Aug;46(8):3250-7.
2 Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors. Bioorg Med Chem. 2016 Mar 1;24(5):1050-62.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.