Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00330)
Xenobiotics Name
Thioridazine hydrochloride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
66062
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [1], [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [3]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Asparagine synthetase (ASNS) DME Info Homo sapiens [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Mephenytoin 4-hydroxylase (CYP2C19) DME Info IC50 = 6.3778 microM [3]
References
1 Down-regulation of aldo-keto reductase AKR1B10 gene expression by a phorbol ester via the ERK/c-Jun signaling pathway. Chem Biol Interact. 2015 Jun 5;234:274-81.
2 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
3 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
4 The mechanism and benefit of human butyrylcholinesterase activation by what would otherwise be inhibitors. Chem Biol Interact. 2019 Aug 1;308:350-356.
5 The androgenic anabolic steroid tetrahydrogestrinone produces dioxin-like effects via the aryl hydrocarbon receptor. Toxicol In Vitro. 2012 Oct;26(7):1129-33.

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