Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00331)
Xenobiotics Name
Ticlopidine hydrochloride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=65335"></iframe>
3D MOL 2D MOL
PubChem CID
65335
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [3]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [1]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [4], [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A2 (CYP1A2) DME Info IC50 = 8.59 microM [1]
Cytochrome P450 2B6 (CYP2B6) DME Info IC50 = 0.6 microM [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info IC50 = 0.6678 microM [3]
Cytochrome P450 2C9 (CYP2C9) DME Info IC50 = 31.1 microM [1]
Cytochrome P450 2D6 (CYP2D6) DME Info IC50 = 4.8 microM [1]
References
1 Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug Metab Dispos. 2013 Jan;41(1):60-71.
2 2-(3-Methoxyphenyl)quinazoline derivatives: a new class of direct constitutive androstane receptor (CAR) agonists. J Med Chem. 2016 May 26;59(10):4601-10.
3 Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. Toxicol In Vitro. 2013 Sep;27(6):2005-12.
4 Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chem Res Toxicol. 2014 Feb 17;27(2):304-308.
5 Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.

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