Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00338)
Xenobiotics Name
Amlodipine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2162
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [3]
NADPH-dependent nitroreductase (nfrA1) DME Info Bacillus subtilis [4]
Glutamate racemase (MurI) DME Info Bacillus subtilis [4]
Glutamate racemase (MurI) DME Info Bacillus pumilus [4]
General stress protein 14 (ywrO) DME Info Bacillus subtilis [4]
References
1 Cell-based high-throughput screening for aromatase inhibitors in the Tox21 10K library. Toxicol Sci. 2015 Oct;147(2):446-57.
2 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
3 Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine. Chem Biol Interact. 2019 Jun 1;306:1-9.
4 Examine the characterization of biofilm formation and inhibition by targeting SrtA mechanism in Bacillus subtilis: a combined experimental and theoretical study. J Mol Model. 2014 Aug;20(8):2364.

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