Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00366)
Xenobiotics Name
Methotrexate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
126941
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Carboxylesterase 2 (CES2) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [3]
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [3]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [3]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [3]
Vitamin B12 methionine synthase (MTR) DME Info Homo sapiens [4]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [5]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [6]
DME(s) Induced by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [7]
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [8]
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [7], [9]
Catalase (CAT) DME Info Homo sapiens [4]
Aromatase (CYP19A1) DME Info Homo sapiens [10]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [9]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [11]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [12]
Methylenetetrahydrofolate reductase (MTHFR) DME Info Homo sapiens [8]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [13]
Phosphodiesterase 7B (PDE7B) DME Info Homo sapiens [14]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [15], [16]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [4], [9]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [8]
Thymidylate synthase (TYMS) DME Info Homo sapiens [3]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [9]
References
1 Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction. Drug Metab Dispos. 2006 Oct;34(10):1742-8.
2 3,4-Methylenedioxymethamphetamine (MDMA) abuse may cause oxidative stress and potential free radical damage. Free Radic Res. 2003 May;37(5):491-7.
3 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
4 UDP-glucuronosyltransferase 1A6 overexpression in breast cancer cells resistant to methotrexate. Biochem Pharmacol. 2011 Jan 1;81(1):60-70.
5 Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. Protein J. 2005 Feb;24(2):65-77.
6 Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro. Toxicol Lett. 2017 Nov 5;281:65-73.
7 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
8 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
9 Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
10 Complex role of zinc in methamphetamine toxicity in vitro. Neuroscience. 2010 Nov 24;171(1):31-9.
11 Methamphetamine alters the normal progression by inducing cell cycle arrest in astrocytes. PLoS One. 2014 Oct 7;9(10):e109603.
12 Serum paraoxonase activity before and after treatment of thyrotoxicosis. Clin Endocrinol (Oxf). 2004 Jan;60(1):75-80.
13 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
14 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
15 Brain antioxidant systems in human methamphetamine users. J Neurochem. 2004 Jun;89(6):1396-408.
16 Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C Delte in human neuroblastoma dopaminergic SH-SY5Y cell lines. J Appl Toxicol. 2015 Aug;35(8):927-44.

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