Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00383)
Xenobiotics Name
Tamoxifen
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2733525
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [6]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [6]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [6]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [7]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2C8 (CYP2C8) DME Info IC50 = 14.3 microM [2]
Cytochrome P450 3A4 (CYP3A4) DME Info IC50 > 30 microM [2]
References
1 Sulindac inhibited gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in T24 human bladder tumor cells. Urol Res. 2001 Dec;29(6):406-11.
2 Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug Metab Dispos. 2012 May;40(5):943-51.
3 Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells. J Agric Food Chem. 2005 Mar 9;53(5):1417-21.
4 Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium. Chem Res Toxicol. 2014 Mar 17;27(3):377-86.
5 Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
6 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
7 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.

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