Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00388)
Xenobiotics Name
Hydrogen peroxide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
784
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alkaline phosphatase (ALPL) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [2]
Catechol O-methyltransferase (COMT) DME Info Homo sapiens [3]
Dimethylaniline oxidase 1 (FMO1) DME Info Homo sapiens [3]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [4]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [5]
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [3]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [6]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [6]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [7]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [8]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [9]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [10]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [6]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [11], [12]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [13], [14]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [15]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [16]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [17]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [18]
Succinic semialdehyde reductase (AKR7A2) DME Info Homo sapiens [18]
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [15]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [19]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [20]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [17]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [21]
Glutathione reductase (GSR) DME Info Homo sapiens [22]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [17]
Myeloperoxidase (MPO) DME Info Homo sapiens [23]
Metallothionein-2A (MT2A) DME Info Homo sapiens [17]
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [24]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [25]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [19], [25]
References
1 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
2 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
3 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
4 Inhibitory effects of myricitrin on oxidative stress-induced endothelial damage and early atherosclerosis in ApoE-/- mice. Toxicol Appl Pharmacol. 2013 Aug 15;271(1):114-26.
5 Protection of LLC-PK1 cells against hydrogen peroxide-induced cell death by modulation of ceramide level. Arch Pharm Res. 2005 Mar;28(3):311-8.
6 Formation of the Pseudomonas aeruginosa PAO1 biofilms in the presence of hydrogen peroxide; the effect of the AiiA gene. Mol Gen Mikrobiol Virusol. 2013;(4):10-4.
7 Cyanamide-mediated inhibition of N-acetyltransferase 1. Toxicology. 2012 Dec 8;302(1):1-10.
8 The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol. 2005 Apr;67(4):1299-306.
9 Trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod. 2013 Jul 26;76(7):1242-7.
10 Hydrogen peroxide responsive miR153 targets Nrf2/ARE cytoprotection in paraquat induced dopaminergic neurotoxicity. Toxicol Lett. 2014 Aug 4;228(3):179-91.
11 Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. J Lipid Res. 2004 Dec;45(12):2211-20.
12 Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. Biochem J. 2003 Oct 15;375(Pt 2):275-85.
13 Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
14 Regulation of copper/zinc and manganese superoxide dismutase by UVB irradiation, oxidative stress and cytokines. J Photochem Photobiol B. 1997 Oct;40(3):288-93.
15 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
16 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
17 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
18 Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. Neurotoxicology. 2012 Oct;33(5):1368-74.
19 Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity. Eur J Biochem. 1999 Oct 1;265(1):27-34.
20 NADPH oxidase-dependent mechanism explains how arsenic and other oxidants can activate aryl hydrocarbon receptor signaling. Chem Res Toxicol. 2015 Dec 21;28(12):2278-86.
21 Oxidative stress induces GSTP1 and CYP3A4 expression in the human erythroleukemia cell line, K562. Biol Pharm Bull. 2004 Apr;27(4):492-5.
22 Comparison of characteristics of peroxide-conditioned immortal human lens-epithelial cell lines with their murine counterparts. Exp Eye Res. 2004 Sep;79(3):411-7.
23 An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity. Toxicol Lett. 2017 Oct 5;280:48-56.
24 T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide. J Immunol. 2003 Nov 15;171(10):5188-97.
25 The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.

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