Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00410)
Xenobiotics Name
Phenobarbital
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
4763
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [2]
Bleomycin hydrolase (BLMH) DME Info Homo sapiens [3]
Catalase (CAT) DME Info Homo sapiens [1], [4]
Aromatase (CYP19A1) DME Info Homo sapiens [5]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [6]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [6]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [6]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [7]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [8]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [9]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [10]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [11]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [12]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [13]
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info Homo sapiens [14]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info Homo sapiens [13], [15]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [16]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [17]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [17]
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME Info Homo sapiens [18]
Cytochrome P450 2A13 (CYP2A13) DME Info Homo sapiens [5]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [6]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [6]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [6]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [6]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [19]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info Homo sapiens [17]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [20], [17]
References
1 Health risk assessment of occupationally pesticide-exposed population of cancer prone area of Punjab. Toxicol Sci. 2018 Sep 1;165(1):157-169.
2 Changes in erythrocyte enzymes in humans long-term exposed to pesticides: influence of several markers of individual susceptibility. Toxicol Lett. 2005 Oct 15;159(1):13-21.
3 Pesticide exposure and genetic variation in xenobiotic-metabolizing enzymes interact to induce biochemical liver damage. Food Chem Toxicol. 2013 Nov;61:144-51.
4 Oxidative stress and genetic damage among workers exposed primarily to organophosphate and pyrethroid pesticides. Environ Toxicol. 2017 Jun;32(6):1754-1764.
5 An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid. J Pharm Biomed Anal. 2013 Dec;86:56-64.
6 High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver. Arch Toxicol. 2017 Jan;91(1):247-258.
7 Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chem Res Toxicol. 2009 Jul;22(7):1325-33.
8 The inhibitory effects of perfluoroalkyl substances on human and rat 11beta-hydroxysteroid dehydrogenase 1. Chem Biol Interact. 2012 Jan 25;195(2):114-8.
9 Modulation of the endogenous antioxidants paraoxonase-1 and urate by pesticide exposure and genetic variants of xenobiotic-metabolizing enzymes. Food Chem Toxicol. 2013 Nov;61:164-70.
10 Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. J Pharmacol Exp Ther. 2005 Dec;315(3):1298-305.
11 Hematological abnormality, oxidative stress, and genotoxicity induction in the greenhouse pesticide sprayers; investigating the role of NQO1 gene polymorphism. Toxics. 2018 Feb 7;6(1).
12 High-affinity binding of fatty acyl-CoAs and peroxisome proliferator-CoA esters to glutathione S-transferases effect on enzymatic activity. Eur J Biochem. 1999 Nov;266(1):143-50.
13 The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol. 2005 Apr;67(4):1299-306.
14 Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation. Biochem Biophys Res Commun. 2017 Jun 17;488(1):136-140.
15 Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study. J Biol Chem. 2004 Feb 27;279(9):7708-14.
16 Phenanthrene decreases neutrophil function by disrupting intracellular redox balance. J Appl Toxicol. 2010 Jul;30(5):476-86.
17 Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36.
18 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
19 Perfluorooctanoic acid (PFOA) affects distinct molecular signalling pathways in human primary hepatocytes. Toxicology. 2015 Jul 3;333:53-62.
20 The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.

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