Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00430)
Xenobiotics Name
Hydroquinone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
785
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Glutamine synthetase (GLUL) DME Info Homo sapiens [1]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [1]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [3]
Arachidonate 12-lipoxygenase (ALOX12B) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Serine sulfhydrase (CBS) DME Info Homo sapiens [1]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1], [4]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [1], [4]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [5]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [6]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [3], [1]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [1]
References
1 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
2 Hydroquinone-induced apoptosis in HL-60 cells. Anticancer Res. 2005 Jan-Feb;25(1A):161-70.
3 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
4 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
5 Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1. J Biol Chem. 2019 Feb 15;294(7):2486-2499.
6 A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8150-5.

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