Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00481)
Xenobiotics Name
Rotenone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
6758
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Bile acid-CoA thioesterase (BAAT) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [2]
Adenosine aminohydrolase (ADA) DME Info Homo sapiens [3]
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [4], [5]
Asparagine synthetase (ASNS) DME Info Homo sapiens [6]
Catalase (CAT) DME Info Homo sapiens [7]
Serine sulfhydrase (CBS) DME Info Homo sapiens [6]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [8]
N-acetyl-beta-glucosaminidase beta (HEXB) DME Info Homo sapiens [9]
Metallothionein-2A (MT2A) DME Info Homo sapiens [7]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [6]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [10], [11]
References
1 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
2 Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58.
3 Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy chinese subjects. Antimicrob Agents Chemother. 2014 Oct;58(10):5987-93.
4 Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine. Biochem Pharmacol. 2011 Dec 1;82(11):1747-56.
5 Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction. Drug Metab Dispos. 2006 Oct;34(10):1742-8.
6 Severe interaction between ritonavir and acenocoumarol. Ann Pharmacother. 2002 Apr;36(4):621-3.
7 Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
8 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
9 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
10 Solomonsterols A and B from Theonella swinhoeiThe first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity. J Med Chem. 2011 Jan 13;54(1):401-5.
11 New brominated flame retardants and their metabolites as activators of the pregnane X receptor. Toxicol Lett. 2016 Sep 30;259:116-123.

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