Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00493)
Xenobiotics Name
Bezafibrate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
39042
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alkaline phosphatase (ALPL) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [2]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [5], [6]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [7]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [8]
References
1 The effect of bezafibrate treatment on serum alkaline phosphatase isoenzyme activities. Metabolism. 1993 Jul;42(7):839-42.
2 Bisphenol A downregulates CYP19 transcription in JEG-3 cells. Toxicol Lett. 2009 Sep 28;189(3):248-52.
3 Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner. Toxicol Appl Pharmacol. 2018 Sep 15;355:156-163.
4 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
5 Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. Toxicol In Vitro. 2009 Oct;23(7):1259-67.
6 CYP4A11 is repressed by retinoic acid in human liver cells. FEBS Lett. 2006 Jun 12;580(14):3361-7.
7 Effects of Bezafibrate on Hepatic Cholesterol Metabolism Eur J Clin Pharmacol. 1991;40 Suppl 1:S33-6.
8 The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism. 2001 Jan;50(1):3-11.

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