Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00536)
Xenobiotics Name
Dihydrotestosterone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
10635
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Serine sulfhydrase (CBS) DME Info Homo sapiens [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [3]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [3]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [3]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [3]
Glutamine synthetase (GLUL) DME Info Homo sapiens [3]
Glutathione reductase (GSR) DME Info Homo sapiens [3]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [3]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [3]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [3]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [3]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [4], [5]
Steroid 5-alpha-reductase 3 (SRD5A3) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [6]
References
1 Testosterone regulation of homocysteine metabolism modulates redox status in human prostate cancer cells. Antioxid Redox Signal. 2007 Nov;9(11):1875-81.
2 Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing different levels of estrogen receptor alpha and beta. J Cell Physiol. 2011 May;226(5):1334-9.
3 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
4 Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters. Environ Int. 2015 Jan;74:60-70.
5 Antiandrogenic mechanisms of pesticides in human LNCaP prostate and H295R adrenocortical carcinoma cells. Toxicol Sci. 2015 Jan;143(1):126-35.
6 Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells. Endocrinology. 2006 Aug;147(8):3843-50.

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