Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00560)
Xenobiotics Name
Triclosan
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
5564
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
Unclear metabolic mechanism (DME-unclear) DME Info Streptococcus mutans [3]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [2]
Glutamate racemase (MurI) DME Info Streptococcus mutans [3]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [4]
Proline dehydrogenase 1 (PRODH) DME Info Homo sapiens [5]
Transglutaminase H (TGM2) DME Info Homo sapiens [6]
Thymidylate synthase (TYMS) DME Info Homo sapiens [7], [8]
DME(s) Induced by This Xenobiotics
Aldehyde dehydrogenase 7 (ALDH7) DME Info Homo sapiens [9]
Arachidonate 15-lipoxygenase (ALOX15) DME Info Homo sapiens [9]
Aquaporin adipose (AQP7) DME Info Homo sapiens [9]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [10]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [11]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [12]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [11]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [11]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [11]
Cytochrome P450 4B1 (CYP4B1) DME Info Homo sapiens [11]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [13]
Dimethylaniline oxidase 1 (FMO1) DME Info Homo sapiens [13]
Gamma-glutamyltranspeptidase 5 (GGT5) DME Info Homo sapiens [14]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [15]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [16]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [2]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [11]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [13]
References
1 Oxidative stress and free radical damage in patients with acute dipterex poisoning. Biomed Environ Sci. 2004 Jun;17(2):223-33.
2 Organotin exposure stimulates steroidogenesis in H295R Cell via cAMP pathway. Ecotoxicol Environ Saf. 2018 Jul 30;156:148-153.
3 Dental composite materials containing carolacton inhibit biofilm growth of Streptococcus mutans. Dent Mater. 2013 Nov;29(11):1188-99.
4 Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides. Toxicol In Vitro. 2019 Apr;56:93-100.
5 Slow-binding inhibition of carboxylesterase and other serine hydrolases by chlorodifluoroacetaldehyde. Chem Res Toxicol. 1993 Sep-Oct;6(5):630-4.
6 Trichlorfon induces apoptosis in SH-SY5Y neuroblastoma cells via the endoplasmic reticulum? Chem Biol Interact. 2009 Sep 14;181(1):37-44.
7 Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
8 Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands. Environ Sci. 2005;12(4):219-30.
9 Trichloroethylene induce nitric oxide production and nitric oxide synthase mRNA expression in cultured normal human epidermal keratinocytes. Toxicology. 2007 Oct 8;239(3):186-94.
10 Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108.
11 Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line. Toxicol Lett. 2008 Feb 15;176(3):230-8.
12 Organophosphorus flame retardants impair intracellular lipid metabolic function in human hepatocellular cells. Chem Res Toxicol. 2019 Jun 17;32(6):1250-1258.
13 Effects of low dose treatment of tributyltin on the regulation of estrogen receptor functions in MCF-7 cells. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):176-86.
14 An investigation of hormesis of trichloroethylene in L-02 liver cells by differential proteomic analysis. Mol Biol Rep. 2009 Nov;36(8):2119-29.
15 Organotin compounds enhance 17beta-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta. Biochem Pharmacol. 2006 Apr 28;71(9):1349-57.
16 Effects of trichlorfon on malondialdehyde and antioxidant system in human erythrocytes. Toxicol In Vitro. 2007 Dec;21(8):1538-44.

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