Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00581)
Xenobiotics Name
MS-275
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4261"></iframe>
3D MOL 2D MOL
PubChem CID
4261
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Retinal dehydrogenase 2 (ALDH1A2) DME Info Homo sapiens [2]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [2]
Beta,beta-carotene 15,15'-dioxygenase (BCO1) DME Info Homo sapiens [2]
DOPA decarboxylase (DDC) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [2]
Adenosine aminohydrolase (ADA) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [2]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [1]
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info Homo sapiens [2]
Serine sulfhydrase (CBS) DME Info Homo sapiens [2]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [2]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [1]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [2]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [2]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [2]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [2]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [2]
Galactose kinase (GALK1) DME Info Homo sapiens [1]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [2]
Glutathione S-transferase omega-2 (GSTO2) DME Info Homo sapiens [1]
N-acetyl-beta-glucosaminidase beta (HEXB) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [2], [1]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [1]
Indoleamine 2,3-dioxygenase 1 (IDO1) DME Info Homo sapiens [2]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [2], [1]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [2]
Neprilysin (MME) DME Info Homo sapiens [2], [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [1]
Alpha-N-acetylglucosaminidase (NAG) DME Info Homo sapiens [2]
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [2]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [2]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [2]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [2]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [1]
Pyridoxamine-phosphate oxidase (PNPO) DME Info Homo sapiens [1]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [1]
Proline dehydrogenase 1 (PRODH) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [1]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [2]
Sulfotransferase 1A2 (SULT1A2) DME Info Homo sapiens [2]
Sulfotransferase 2B1 (SULT2B1) DME Info Homo sapiens [1]
Transglutaminase H (TGM2) DME Info Homo sapiens [1]
References
1 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
2 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.