Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00596)
Xenobiotics Name
Phenethyl isothiocyanate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
16741
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [1]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [6]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [7]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2A6 (CYP2A6) DME Info Ki = 1.7 microM [1]
Cytochrome P450 2E1 (CYP2E1) DME Info Ki = 11 microM [2]
References
1 Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes. Drug Metab Dispos. 2012 Sep;40(9):1797-802.
2 The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation. Drug Metab Dispos. 2013 Apr;41(4):858-69.
3 An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid. J Pharm Biomed Anal. 2013 Dec;86:56-64.
4 Cultured human peripheral blood mononuclear cells alter their gene expression when challenged with endocrine-disrupting chemicals. Toxicology. 2013 Jan 7;303:17-24.
5 High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver. Arch Toxicol. 2017 Jan;91(1):247-258.
6 Evaluation of perfluoroalkyl acid activity using primary mouse and human hepatocytes. Toxicology. 2013 Jun 7;308:129-37.
7 Effects of perfluorooctanoate and perfluorooctane sulfonate exposure on hepatoma Hep G2 cells. Arch Toxicol. 2009 Sep;83(9):851-61.

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