Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00605)
Xenobiotics Name
Oltipraz
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
47318
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [3]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [3], [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A2 (CYP1A2) DME Info Ki = 9 microM [1]
References
1 Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54.
2 Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells. Food Chem Toxicol. 2018 Dec;122:59-68.
3 Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors. Drug Chem Toxicol. 2012 Jan;35(1):71-80.
4 Modulation of the xenobiotic transformation system and inflammatory response by ochratoxin A exposure using a co-culture system of Caco-2 and HepG2 cells. Food Chem Toxicol. 2015 Dec;86:245-52.

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