Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00636)
Xenobiotics Name
Xanthohumol
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
639665
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [1]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Alkaline phosphatase (ALPL) DME Info Homo sapiens [3]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [4]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [5]
Glutathione S-transferase theta-1 (GSTT1) DME Info Homo sapiens [6], [7]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [8]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [4], [9]
References
1 Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophages. Toxicol In Vitro. 2004 Jun;18(3):377-91.
2 Disruption of the integrity and function of brain microvascular endothelial cells in culture by exposure to diesel engine exhaust particles. Toxicol Lett. 2013 Jun 20;220(1):1-7.
3 Diesel exhaust particles (DEP) pre-exposure contributes to the anti-oxidant response impairment in hCMEC/D3 during post-oxygen and glucose deprivation damage. Toxicol Lett. 2017 May 15;274:1-7.
4 Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles. J Immunol. 2006 Sep 1;177(5):3477-83.
5 Time course of bronchial cell inflammation following exposure to diesel particulate matter using a modified EAVES. Toxicol In Vitro. 2014 Aug;28(5):829-37.
6 Diesel exhaust particulate associated chemicals attenuate expression of CXCL10 in human primary bronchial epithelial cells. Toxicol In Vitro. 2017 Dec;45(Pt 3):409-416.
7 Alteration of peripheral blood monocyte gene expression in humans following diesel exhaust inhalation. Inhal Toxicol. 2012 Feb;24(3):172-81.
8 Role of neprilysin in airway inflammation induced by diesel exhaust emissions. Res Rep Health Eff Inst. 2011 Jun;(159):3-40.
9 Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L671-9.

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