Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00656)
Xenobiotics Name
Sulindac sulfide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
5352624
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Arachidonate 15-lipoxygenase (ALOX15) DME Info Homo sapiens [4]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Methionine-tRNA ligase mitochondrial (MARS2) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [5]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [5]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [5]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Prostaglandin G/H synthase 1 (COX-1) DME Info IC50 = 0.115 microM [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 0.1 microM [3]
References
1 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
2 Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. J Med Chem. 2012 Mar 8;55(5):2287-300.
3 Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity. J Med Chem. 2010 Jun 24;53(12):4691-700.
4 Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). Drug Metab Dispos. 2008 Dec;36(12):2556-63.
5 Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142.
6 Relative expression of cholesterol transport-related proteins and inflammation markers through the induction of 7-ketosterol-mediated stress in Caco-2 cells. Food Chem Toxicol. 2013 Jun;56:247-53.

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