Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00710)
Xenobiotics Name
Isoliquiritigenin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
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3D MOL 2D MOL
PubChem CID
638278
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [2], [3]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [4]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [5]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [6]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Prostaglandin G/H synthase 1 (COX-1) DME Info IC50 = 130 microM [4]
Prostaglandin G/H synthase 2 (COX-2) DME Info IC50 = 130 microM [4]
References
1 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
2 Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48.
3 Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):10-20.
4 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. J Med Chem. 1993 Nov 26;36(24):3904-9.
5 Differential effects of Glycyrrhiza species on genotoxic estrogen metabolism: licochalcone A downregulates P450 1B1, whereas isoliquiritigenin stimulates it. Chem Res Toxicol. 2015 Aug 17;28(8):1584-94.
6 Induction of NAD(P)H:quinone oxidoreductase 1 (NQO1) by Glycyrrhiza species used for women's health: differential effects of the michael acceptors isoliquiritigenin and licochalcone A. Chem Res Toxicol. 2015 Nov 16;28(11):2130-41.

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