Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00749)
Xenobiotics Name
Teriflunomide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
54684141
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Choline dehydrogenase (CHDH) DME Info Homo sapiens [1]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4], [3]
References
1 Mitochondrial dysfunction induced by leflunomide and its active metabolite. Toxicology. 2018 Mar 1;396-397:33-45.
2 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
3 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease. Pharmacol Res. 2015 Oct;100:64-72.
4 Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.

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