Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00755)
Xenobiotics Name
Coal tar
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Mixture
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1], [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [3]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
Cytochrome P450 2C18 (CYP2C18) DME Info Homo sapiens [3]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [4], [5]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [3]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [3]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [6], [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
References
1 Inducibility of arylhydrocarbon-hydroxylase activity in human hair follicles by topical application of liquor carbonis detergens (coal tar). Br J Dermatol. 1984 Sep;111(3):279-84.
2 Effect of a standardized complex mixture derived from coal tar on the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons in human cells in culture. Chem Res Toxicol. 2005 Feb;18(2):224-31.
3 Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo. Br J Dermatol. 2006 Aug;155(2):275-81.
4 CYP2S1: a short review. Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):62-9.
5 Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Lancet. 2003 Apr 19;361(9366):1336-43.
6 Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest. 2013 Feb;123(2):917-27.

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