Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00768)
Xenobiotics Name
Dichlorodiphenyl dichloroethylene
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Environmental Pollutant
Structure
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3D MOL 2D MOL
PubChem CID
3035
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [2]
Steroid 5-alpha-reductase 2 (SRD5A2) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [4]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [5]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [6]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [6]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [7]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [8], [9]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [9]
References
1 p, p'-Dichlorodiphenyldichloroethylene induces colorectal adenocarcinoma cell proliferation through oxidative stress. PLoS One. 2014 Nov 11;9(11):e112700.
2 Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol Appl Pharmacol. 2007 Jul 15;222(2):129-40.
3 Effects of various pesticides on human 5alpha-reductase activity in prostate and LNCaP cells. Toxicol In Vitro. 2007 Apr;21(3):502-8.
4 An in vivo bioassay for detecting antiandrogens using humanized transgenic mice coexpressing the tetracycline-controlled transactivator and human CYP1B1 gene. Int J Toxicol. 2005 May-Jun;24(3):157-64.
5 Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017 Jul;226:268-276.
6 A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells. J Toxicol Sci. 2010 Aug;35(4):515-25.
7 Organochlorine pesticide-mediated induction of NADPH oxidase and nitric-oxide synthase in endothelial cell. J Clin Diagn Res. 2017 Jan;11(1):BC09-BC12.
8 Differential effect of DDT, DDE, and DDD on COX-2 expression in the human trophoblast derived HTR-8/SVneo cells. J Biochem Mol Toxicol. 2012 Nov;26(11):454-60.
9 Mechanisms of p,p'-DDE-induced apoptosis in human peripheral blood mononuclear cells. Toxicol In Vitro. 2009 Sep;23(6):1000-6.

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