Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00809)
Xenobiotics Name
Thapsigargin
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=446378"></iframe>
3D MOL 2D MOL
PubChem CID
446378
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info Homo sapiens [1], [2]
DOPA decarboxylase (DDC) DME Info Homo sapiens [1], [2]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1], [2]
Hypoxanthine phosphoribosyltransferase (HPRT1) DME Info Homo sapiens [3]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1], [2]
Propionyl-CoA carboxylase beta (PCCB) DME Info Homo sapiens [1], [2]
Thymidylate synthase (TYMS) DME Info Homo sapiens [4], [5]
DME(s) Induced by This Xenobiotics
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [6], [7]
Cytosolic branched aminotransferase (BCAT1) DME Info Homo sapiens [6]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [8]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [9]
References
1 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
2 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
3 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
4 The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko. Toxicol Sci. 2012 Jan;125(1):310-7.
5 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
6 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
7 Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicol Sci. 2009 Nov;112(1):229-44.
8 Differential toxicogenomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin in malignant and nonmalignant human airway epithelial cells. Toxicol Sci. 2002 Oct;69(2):409-23.
9 Characterization of the pattern of the nongenomic signaling pathway through which TCDD-induces early inflammatory responses in U937 human macrophages. Chemosphere. 2009 Mar;74(11):1531-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.