Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00818)
Xenobiotics Name
Phenylmercuric acetate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
16682730
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldehyde oxidase (AOX1) DME Info Homo sapiens [1]
Arsenite methyltransferase (AS3MT) DME Info Homo sapiens [1]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [2]
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [3]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [4], [5]
Asparagine synthetase (ASNS) DME Info Homo sapiens [6]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [7], [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [6]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [8], [9]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [10]
Glutathione reductase (GSR) DME Info Homo sapiens [11]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [12]
Heparanase (HPSE) DME Info Homo sapiens [13]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [5]
Metallothionein-2A (MT2A) DME Info Homo sapiens [10]
Glutamine-dependent NAD(+) synthetase (NADSYN1) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [14]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [15]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [6]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [1]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [16]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [10]
Sulfotransferase 1A2 (SULT1A2) DME Info Homo sapiens [6]
References
1 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
2 Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):326-32.
3 Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
4 Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. Drug Metab Dispos. 2003 May;31(5):620-30.
5 Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes. Drug Metab Dispos. 2005 Jul;33(7):1004-16.
6 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
7 Xenobiotic CAR activators induce Dlk1-Dio3 locus noncoding RNA expression in mouse liver. Toxicol Sci. 2017 Aug 1;158(2):367-378.
8 Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol. 2006 Jul;70(1):329-39.
9 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
10 Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
11 Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model. J Appl Toxicol. 2016 Feb;36(2):320-9.
12 Functional expression, inhibition and induction of CYP enzymes in HepaRG cells. Toxicol In Vitro. 2009 Jun;23(4):748-53.
13 Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
14 Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58.
15 HepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screening. J Appl Toxicol. 2015 Aug;35(8):909-17.
16 Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35.

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